Construction of β-cyclodextrin-based supramolecular hyperbranched polymers self-assemblies using AB2-type macromonomer and their application in the drug delivery field.
作者：Bai, Y.,* Liu, C.P., Xie, F.Y., Ma, R., Zhuo, L.H., Li, N., Tian, W.*
關(guān)鍵字：Supramolecular hyperbranched polymer， β-Cyclodextrin， Host-guest interactions， Self-assembly behavior， Drug delivery
論文來源：期刊
具體來源：Carbohydrate Polymers. 2019, 213, 411-418.
發(fā)表時間：2019年
Despite some e?orts have been made in the research of supramolecular hyperbranched polymers (SHPs) selfassemblies, the study which has not been consideration to date is the in?uence of incoming stimuli-responsive polymer chain on their self-assembly property undergo outer stimuli. The introduction of stimuli-responsive segments which could maintain their hydrophilic property are expected to a?ect the self-assembly behaviour of SHPs and expand their further biomedical application. In this paper, AB2-type macromolecular monomer, LA-(CD-PDMA)2, which consisted one lithocholic acid (LA) and two β-cyclodextrin terminated poly(2-(dimethylamino)ethyl methacrylate) segments (CD-PDMA) was synthesized. LA-(CD-PDMA)2 based SHP were obtained based on the host-guest inclusion interactions of CD/LA moietes and with PDMA as pH-responsive hydrophilic chains. As a control to study the in?uence of incoming PDMA chains, both LA-(CD-PDMA)2 based SHPs-1 and LA-CD2 based SHPs-2 self-assemblies were comparatively investiged through 2D 1H NMR ROESY, transmission electron microscopy (TEM) and dynamic light scattering (DLS). The results suggested that except for the higher drug loading efciency LA-(CD-PDMA)2 based SHPs-1 pocessing, the release rates of SHPs-1 increased notably at pH 5.0 than that of pH 7.4 due to the repulsion and stretch of protonated PDMA chains while the release rates of SHPs-2 showed no obvious di?erence. Finally, basic cell experiments demonstrated that the SHPs based selfassemblies can be internalized into cancer cells, indicating their potential application in the drug delivery feld