Advances in polyelectrolyte multilayer nanofilms as tunable drug delivery systems
作者：Jiang B, Barnett J, Li B.
關鍵字：nanofilm, polyelectrolyte multilayer, drug delivery, electrostatic layer-by-layer self-assembly, biomedical device, surface modification
論文來源：期刊
具體來源：Nanotechnology, Science and Applications
發表時間：2009年
There has been considerable interest in polyelectrolyte multilayer nanofilms, which have a variety of applications ranging from optical and electrochemical materials to biomedical devices. Polyelectrolyte multilayer nanofilms are constructed from aqueous solutions using electrostatic layer-by-layer self-assembly of oppositely-charged polyelectrolytes on a solid substrate. Multifunctional polyelectrolyte multilayer nanofilms have been studied using charged dyes, metal and inorganic nanoparticles, DNA, proteins, and viruses. In the past few years, there has been increasing attention to developing polyelectrolyte multilayer nanofilms as drug delivery vehicles. In this mini-review, we present recent developments in polyelectrolyte multilayer nanofilms with tunable drug delivery properties, with particular emphasis on the strategies in tuning the loading and release of drugs in polyelectrolyte multilayer nanofilms as well as their applications.