Near-infrared light-triggered and separable microneedles for on-demand transdermal delivery of metformin on diabetic rats
作者：Yang Zhang, Danfeng Wang, Mengyue Gao, Bin Xu, Jiangyin Zhu, Weijiang Yu, Depeng Liu, and Guohua Jiang*
關(guān)鍵字：microneedles, transdermal delivery, diabetes, hypoglycemic effect, near-infrared (NIR) light
論文來源：期刊
具體來源：ACS Biomaterials Science & Engineering
發(fā)表時間：2018年
Abstract: The near-infrared (NIR) light-triggered and separable segmented microneedles (MNs), consisted of lauric acid and polycaprolactone (LA/PCL) arrowheads and polyvinyl alcohol and polycaprolactone (PVA/PVP) supporting bases, have been fabricated. The hypoglycemic drug (metformin) and photothermal conversion factor (Cu7S4 nanoparticles) are capsulated into LA/PCL arrowheads. Owing to the dissolution of soluble supporting bases after absorption of tissue fluid, the separable MNs arrowheads can be embedded into skin after insertion. Under the near-infrared (NIR) light irradiation, the LA/PCL arrowheads exhibit an excellent thermal ablation change with low amount of Cu7S4 nanoparticles (0.1 wt%) due to the low melting point of LA and PCL, thus enabling the release behavior of encapsulated model drug to be photothermal triggered. Compared with hypodermic injection of metformin, a thermal ablation of separable MNs triggered with NIR irradiation in current research exhibit an excellent hypoglycemic effect in vivo. It suggests that the NIR-induced thermal ablation MNs is a prospective transdermal drug delivery system for precise control of timing and dosage of the drug dependent on a NIR administration.
