Integration of metformin-loaded MIL-100(Fe) into hydrogel microneedles for prolonged regulation of blood glucose levels
作者：Mingjia Feng,# Yan Li,# Yanfang Sun, Tianqi Liu, Khaydar E. Yunusov, Guohua Jiang,*
關鍵字：Biomaterials, microstructure, microneedles, transdermal delivery, hypoglycemic effect
論文來源：期刊
具體來源：Biomedical Physics & Engineering Express
發表時間：2024年
Abstract: The transdermal drug delivery based on microneedles (MNs) provides a suitable and painless self-administration for diabetic patients. In this work, the hydrogel-forming MNs were firstly fabricated using poly(vinyl alcohol) (PVA) and chitosan (CS) as matrix. A hypoglycemic drug, metformin (Met), had been loaded into MIL-100(Fe). Then, both of free Met and Met-loaded MIL-100(Fe) were integrated into hydrogel-forming MNs for regulation of blood glucose levels (BGLs) on diabetic rats. After penetrated into the skin, the free Met could be firstly released from MNs. Due to the absorption of interstitial fluid and subsequent release of loaded Met from MIL-100(Fe), leading to a sustainable and long-term drug release behaviors. A notable hypoglycemic effect and low risk of hypoglycemia could be obtained on diabetic rat models in vivo. The as-fabricated hydrogel-forming MNs expected to become a new type of transdermal drug delivery platform for transdermal delivery of high-dose drugs to form a long-term hypoglycemic effect.
Keywords: Biomaterials, microstructure, microneedles, transdermal delivery, hypoglycemic effect