A three-dimensional printable conductive composite dressing for accelerating wound healing under electrical stimulation
作者：Xinxiang Chai, Yanzhen Lou, Lei Nie Amin Shavandi, Khaydar E. Yunusov, Yanfang Sun, Guohua Jiang*
關鍵字：conductive dressings, 3D printing, electrical stimulation, wound healing
論文來源：期刊
具體來源：Colloids and Surfaces B: Biointerfaces
發(fā)表時間：2024年
Abstract: In this study, a bioink based on poly(vinyl alcohol) (PVA) and k-carrageenan network was prepared using conductive polymer (PEDOT:PSS) as conducting medium, and (+)-Catechin-loaded mesoporous ZnO (CmZnO) as antibacterial and anti-inflammatory active medium. 3D conductive composite dressing was further fabricated by an extrusion 3D printing technology. Our results showed that the as-obtained composite dressing had suitable conductivity, efficient blood clotting capacity, and good adhesiveness. It also showed that the as-fabricated conductive composite had 92.9% and 95.6% antibacterial activity against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), respectively. Furthermore, the conductive dressing with an optimal electrical stimulation (ES) parameter showed in vivo blood clotting capacity, and it enhanced in vivo wound healing process in a full-thickness skin defect model than commercial dressings by upregulating the gene expression of growth factors including CD-31 and downregulating inflammatory factor expression of IL-6.
Keywords: conductive dressings, 3D printing, electrical stimulation, wound healing
