【Acta Biomaterialia, IF= 9.4】Bioinspired Janus Mesh with Mechanical Support and Side-specific Biofunctions for Hernia Repair
作者：Hiaoli Han, Zhenliang Liu, Liwei Sun*, Zexiang Li, Lu Zhou, Lingwan Hao*, Jie Zhao, Rujian Jiang*
關(guān)鍵字：Janus Mesh, Anti-inflammatory, Antibacterial, Antiadhesion
論文來源：期刊
發(fā)表時(shí)間：2024年
Postoperative adhesion (PA) caused by the combination of proteins, inflammatory response and bacterial infection poses substantial challenges for polypropylene meshes (PPMs) based hernioplasty. Herein, inspired by the peritoneum, a Janus PPMs with side-specific functions was developed via a surface-initiated photoinifertermediated polymerization technology. A physical barrier composed of zwitterionic polymer brushes (PS) was firstly constructed on the one side of the PPMs, while the polymethacrylic acid (PMAA) brushes acting as the linker for bioactive nanoparticles (HAP) were precisely situated on the opposite surface subsequently. Our findings reveal that the mesh surface modified with PS demonstrated significant antifouling property that more than 99% of protein adhesion could be inhibited even after the co-incubation for 72 h in the crucial test. Meanwhile, on the other surface of the PPMs modified with HAP achieved satisfactory ROS-scavenging, inflammation-inhibiting and cell adhesion-promoting properties as well as good bactericidal performance (killing rate > 99.9%). Furthermore, the Janus PPMs could maintain comparable mechanical property with pristine meshes. Equipped with the above multiple merits and asymmetric property, the constructed Janus PPMs demonstrated effective treatment for abdominal hernia defects in vivo without any PA formation. Overall, this study duplicates the unique characteristics of peritoneum onto PPMs to successfully address postoperativ complications of the hernioplasty and also offers a versatile and innovative idea to construct asymmetrical functions on the one implant.