[ACS Biomater. Sci. Eng.] Drug Self-Assembled Delivery System with Dual Responsibility for Cancer Chemotherapy
作者：Xiao Duan, Heng Chen, Li Fan and Jie Kong*
關(guān)鍵字：Drug Self-Assembled Delivery System, Cancer Chemotherapy
論文來源：期刊
具體來源：ACS Biomaterials Science & Engineering, 2016, 2, 2347-2354
發(fā)表時間：2016年
Xiao Duan, Heng Chen, Li Fan and Jie Kong*, Drug Self-Assembled Delivery System with Dual Responsibility for Cancer Chemotherapy, ACS Biomaterials Science & Engineering, 2016, 2, 2347-2354
論文鏈接：http://pubs.acs.org/doi/abs/10.1021/acsbiomaterials.6b00559
ABSTRACT: In this study, we present a novel drug self-assembled delivery system (DSD) with pH and glutathione dual responsiveness to synergistically address the problems of traditional polymer-based carriers, i.e., their low drug loading efficiency, poor biocompatibility and nonbiodegradability. The DSD system with minimum assistant substances was developed from methotrexate (MTX) model drug copolymers and polyethylene glycol (PEG), which gives the system a higher drug loading efficiency and completely avoids the use of toxic carriers. The amphiphilic block copolymers of MTX and PEG are self-assembled into stable micelles such that MTX can be delivered to tumor tissues in vivo and controllable release can be achieved for cancer therapy via the cleavage of the reversible covalent bonds in the copolymer. The micelles overlapped with lysosomes for cellular uptake, and the in vivo distribution was higher in tumor tissues. Biological evaluation and histological analysis confirmed that the DSDS micelles were more effective in killing tumor cells than free MTX. In addition, there were fewer side effects in normal tissues. As a result, tumor growth could be effectively inhibited in vivo. The DSD concept is a perfect emerging strategy to address the problems of traditional polymer-based anticancer drug carriers in a synergetic manner and offers new potential routes of cancer therapy and clinical treatments.