208. Novel Method to Graft Chitosan on the Surface of Hydroxyapatite Nanoparticles via “Click” Reaction.
writer：J. C. Wei*, P. Y. Guo-Wang, L. G. Cui, H. B. Zhang, Y. F. Dai, T. X. Liu*
keywords：Hydroxyapatite, Chitosan, Surface modification, Nanocomposite, Biomaterial
source：期刊
specific source：Chemical Research in Chinese Universities, 2014, 30(6), 1063-1065.
Issue time：2014年
In order to tune the surface properties of hydroxyapatite(HA) nanoparticles and prevent them from aggregation, an efficient method was proposed to graft chitosan(CS) molecules on the surface of HA via “click” reaction. Thermal gravimetric analysis(TGA) shows that CS was successfully grafted on the surface of HA nanoparticles and the grafting amount was about 8.9 g of CS on per hundred grams of HA. The grafted chitosan chains can prevent HA nanoparticles from aggregation and greatly enhance the colloidal stability of HA in water. The 3-(4,5-dimethylthiazoyl-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay demonstrats that the cytotoxicity of CS modified HA(HA-CS) is negligible and thus HA-CS may find potential application in biomedical fields.