【Applied Surface Science】Enzyme-mimicking polymer brush-functionalized surface for combating biomaterial-associated infections
writer：Rujian Jiang, Huawei Yang, Lingjie Song, Shunjie Yan, Shifang Luan*, Jinghua Yin, et al.,
keywords：Enzyme-mimicking polymer brush, Photografting polymerization, DNA cleavage, Antibacterial surface, Biomimetic surface
source：期刊
specific source：Applied Surface Science, 2017, 423, 869-880
Issue time：2017年
Abstract:
Biomaterial-associated infections critically compromise the functionality and performance of the medical devices, and pose a serious threat to human healthcare. Recently, natural DNase enzyme has been recognized as a potent material to prevent bacterial adhesion and biofilm formation. However, the vulnerability of DNase dramatically limits its long-term performance in antibacterial applications. In this work, DNase-mimicking polymer brushes were constructed to mimic the DNA-cleavage activity as well as the macromolecular scaffold of the natural DNase. The bacteria repellent efficacy of DNase-mimicking polymer brush-functionalized surface was comparable to that of the DNase-functionalized surface. More importantly, due to their inherent stability, DNase-mimicking polymer brushes presented the much better performance in inhibiting bacterial biofilm development for prolonged periods of time, as compared to the natural DNase. The as-developed DNase-mimicking polymer brush-functionalized surface presents a promising approach to combat biomaterial-associated infections.