NIR photoregulated theranostic system based on hexagonal-phase upconverting nanoparticles for tumor-targeted photodynamic therapy and fluorescence imaging
作者：Linlin Zhao, Jongseon Choi, Yan Lu,* and So Yeon Kim*
關(guān)鍵字：upconversion nanoparticle; photoluminescence; photodynamic therapy; fluorescence imaging
論文來源：期刊
具體來源：Nanomaterials, 2020, 10, 2332
發(fā)表時間：2020年
Although photodynamic therapy (PDT) is an e ective, minimally invasive therapeutic
modality with advantages in highly localized and specific tumor treatments, large and deep-seated cancers within the body cannot be successfully treated due to low transparency to visible light. To improve the therapeutic eciency of tumor treatment in deep tissue and reduce the side e ects in normal tissue, this study developed a near-infrared (NIR)-triggered upconversion nanoparticle (UCNP)-based photosensitizer (PS) carrier as a new theranostics system. The NaYF4:Yb/Er UCNPs were synthesized by a hydrothermal method, producing nanoparticles of a uniformly small size (20 nm) and crystalline morphology of the hexagonal phase. These UCNPs were modified with folic acid-conjugated biocompatible block copolymers through a bidentate dihydrolipoic acid linker. The polymer modified hexagonal phase UCNPs (FA-PEAH-UCNPs) showed an improved dispersibility in the aqueous solution and strong NIR-to-vis upconversion fluorescence. The hydrophobic PS, pheophorbide a (Pha), was then conjugated to the stable vectors. Moreover, these UCNP-based Pha carriers containing tumor targeting folic acid ligands exhibited the significantly enhanced cellular uptake eciency as well as PDT treatment eciency. These results suggested that this system could extend the excitation wavelength of PDT to the NIR region and e ectively improve therapeutic eciency of PSs.