Abstract
全文鏈接：http://pubs.acs.org/doi/abs/10.1021/acsami.5b01687
Two new poly(ortho ester amide)
copolymers (POEA-4 and POEA-5) were synthesized via polycondensation of a new
ortho ester diamine monomer with active esters of different aliphatic diacids.
The kinetics of POEA mass loss and release of 5-FU were both nearly zero-order,
suggesting predominantly surface-restricted polymer erosion and drug release. In
vitro cytotoxicity tests demonstrated that both copolymers have excellent
biocompatibility. In vivo acute toxicity tests suggested that oral
administration of POEA-4 and POEA-5 did not cause any adverse effects on mice
even at a very high dose (2000 mg/kg). In vivo antitumor efficacy against H22
transplanted tumors of 5-FU-loaded POEA tablets were fully examined. We envision
that, with further optimization, POEA-based materials could have great potential
as drug carriers for oral chemotherapy.