私密直播全婐app免费大渔直播,国产av成人无码免费视频,男女同房做爰全过程高潮,国产精品自产拍在线观看

當前位置:群英聚首 > 論文著作 > 正文
An acceptor–donor–acceptor structured small molecule for effective NIR triggered dual phototherapy of cancer
來源:陸燕研究員個人網站 發布日期:2020-12-29
作者:Zheng He, Linlin Zhao, Qiang Zhang, Meijia Chang, Chenxi Li, Hesheng Zhang, Yan Lu*, Yongsheng Chen*
關鍵字:Dual phototherapy; PDT
論文來源:期刊
具體來源:Adv. Funct. Mater., 2020, 30, 1910301.
發表時間:2020年

Dual phototherapy, including photodynamic therapy (PDT) and

photothermal therapy (PTT), is regarded as a more effective method for

cancer treatment than single PDT or PTT. However, development of single

component and near-infrared (NIR) triggered agents for efficient dual

phototherapy remains a challenge. Herein, a simple strategy to develop

dual-functional small-molecules-based photosensitizers for combined

PDT and PTT treatment is proposed through: 1) finely modulating

HOMO–LUMO energy levels to regulate the intersystem crossing (ISC)

process for effective singlet oxygen (1O2) generation for PDT; 2) effectively

inhibiting fluorescence via strong intramolecular charge transfer (ICT) to

maximize the conversion of photo energy to heat for PTT or ISC process

for PDT. An acceptor–donor–acceptor (A-D-A) structured small molecule

(CPDT) is designed and synthesized. The biocompatible nanoparticles,

FA-CNPs, prepared by encapsulating CPDT directly with a folate

functionalized amphipathic copolymer, present strong NIR absorption,

robust photostability, cancer cell targeting, high photothermal conversion

efficiency as well as efficient 1O2 generation under single 808 nm laser

irradiation. Furthermore, synergistic PDT and PTT effects of FA-CNPs

in vivo are demonstrated by significant inhibition of tumor growth. The

proposed strategy may provide a new approach to reasonably design and

develop safe and efficient photosensitizers for dual phototherapy against

cancer.


Copyright © 2005 Polymer.cn All rights reserved
中國聚合物網 版權所有
經營性網站備案信息

京公網安備11010502032929號

工商備案公示信息

京ICP證050801號

京ICP備12003651號

主站蜘蛛池模板: 上高县| 大冶市| 剑河县| 休宁县| 武平县| 玉环县| 河间市| 江永县| 荔浦县| 邹平县| 额济纳旗| 信阳市| 锡林郭勒盟| 江孜县| 三河市| 鄄城县| 陆河县| 临泉县| 温宿县| 湘乡市| 张家界市| 普安县| 扬州市| 延津县| 台北县| 同心县| 临沧市| 独山县| 潍坊市| 泾川县| 高淳县| 徐汇区| 渝中区| 兰考县| 辉南县| 凤山市| 大邑县| 左云县| 丰宁| 亳州市| 通道|