私密直播全婐app免费大渔直播,国产av成人无码免费视频,男女同房做爰全过程高潮,国产精品自产拍在线观看

當前位置:群英聚首 > 論文著作 > 正文
Imidazole-molecule-capped chitosan-gold nanocomposites with enhanced antimicrobial activity for treating biofilm-related infections
來源:陸飛副教授個人網站 發布日期:2023-12-22
作者:Lu, Bitao; Lu, Fei; Ran, Luoxiao et al.
關鍵字:wound healing
論文來源:期刊
具體來源:Journal of Colloid and Interface Science
發表時間:2018年
Biofilms that are widely associated with persistent bacterial infections impose a heavy burden on patients primarily due to their formidable resistance to conventional antiseptic drugs and local immune defense. Here, we successfully synthesized functional gold nanocomposites (CS-Au@MMT) by reducing chloroauric acid in the presence of biocompatible chitosan polymers with cationic amine and the small molecule 2-mercapto-1-methylimidazole (MMT). The cationic amine allowed transport of the CS-Au@MMT to the negatively charged sites at the surface of bacterial cells though electrostatic adhesion, with synergistic effects from the gold nanoparticles and MMT then exerting a strong bactericidal effect to inhibit biofilm formation. For established mature biofilms, CS-Au@MMT was able to adhere to the biofilm surface to render nearby bacterial cells inactive, resulting in biofilm rupture. This allowed CS-Au@MMT to penetrate through the biofilm, leading to sustained damage and achieving biofilm elimination. Furthermore, the nanocomposites efficiently inhibited infections induced by mature biofilm in vivo. These findings indicated that the CS-Au@MMT nanocomposites provide ease of synthesis and fabrication, high bactericidal effect, and low toxicity; thus, they show potential as biofilm-disrupting agents for biomedical and industrial applications. (C) 2018 Elsevier Inc. All rights reserved.
Copyright © 2005 Polymer.cn All rights reserved
中國聚合物網 版權所有
經營性網站備案信息

京公網安備11010502032929號

工商備案公示信息

京ICP證050801號

京ICP備12003651號

主站蜘蛛池模板: 仪征市| 游戏| 白沙| 腾冲县| 沙河市| 九台市| 淮滨县| 固原市| 斗六市| 淮安市| 石狮市| 百色市| 六枝特区| 禄劝| 河西区| 天水市| 寻甸| 娱乐| 荃湾区| 高台县| 富源县| 宁远县| 罗山县| 稷山县| 湟中县| 泸西县| 清远市| 望江县| 太原市| 海原县| 泉州市| 吴堡县| 海口市| 嘉禾县| 汤原县| 宁晋县| 安陆市| 隆化县| 桐梓县| 铜鼓县| 保定市|