作者：Jan Duchek, Mu-Hua Huang, Andrea Vasella*,
關(guān)鍵字：Antifungals,Synthesis,Carbohydrates,Heterocycles
論文來源：期刊
具體來源：Tetrahedron Letters
發(fā)表時(shí)間：2011年
Guanofosfocins are strong inhibitors of chitin synthases, but also very prone to hydrolytic cleavage. Two advanced intermediates 15 and 20 for the synthesis of stable di-carba-guanofosfocins were prepared via ester 11. Acylation of the allylic C-glycoside 6 with riburonic acid chloride 10 afforded ester 11 in 79% yield. This ester was converted to 15 in four steps and in 54% yield and to 20 in eight steps and in 20%
yield.