私密直播全婐app免费大渔直播,国产av成人无码免费视频,男女同房做爰全过程高潮,国产精品自产拍在线观看

當(dāng)前位置:群英聚首 > 論文著作 > 正文
Biodegradable nano-composite polymer scaffolds for bone tissue engineering
作者:7. Peibiao Zhang, Yang Cui, Zhi Wang, Xin Wang, Xiuli Zhuang, and Xuesi Chen
關(guān)鍵字:poly(lactide-co-glycolide), hydroxyapatite, nano-composite, bone repair
論文來(lái)源:會(huì)議
具體來(lái)源:The 5th Asian International Symposium on Biomaterials. Xiamen China, November 15~18
發(fā)表時(shí)間:2006年
 

Although hydroxyapatite (HA) ceramics has good osteoconductivity and osteoinductivity, the brittleness and fatigue failure in the body limit their clinical applications. Recent development of biodegradable polymers, mainly polyesters such as poly(L-lactic acid ) (PLLA), poly(glycolic acid) (PGA) and their copolymers (PLGA), is an attractive approach for tissue engineering with a wide range of mechanical properties, better biocompatibility and unlimited availability. Combination of HA particles and the polymers provides a new stragety to improve their biocompatibility and mechanical properties. However, the interface compatibility of the blend only left lower uniformity and limited mechanical properties. A novel nano-composites of PLLA/gHA were obtained in our lab through the hydroxyl groups on the surface of the HA nano-particles grafted with poly(L-lactide)(PLLA), and its blend with poly(lactide-co-glycolide) (PLGA) were achieved with higher mechanical property and stability. The blend was fabricated into porous scaffolds for bone tissue engineering by porogen leaching method. The growth factor(BMP-2) and RGD copolymer were incorporated into the scaffolds to improve their biological activities. Osteoblasts adhesion, growth and differentiation in the scaffolds were investigated by morphological analysis, RT-PCR and AKP detection. The scaffolds were seeded with autogenic MSCs of rabbits in vitro, and grafted to repair the bone defects of rabbits. The results showed that MSCs attached and grew well in the scaffolds in vitro, and new bones were formed and fused in the area of bone defects rapidly in animal tests. The material showed a wide application in tissue engineering and clinical orthopaedics.

Copyright © 2005 Polymer.cn All rights reserved
中國(guó)聚合物網(wǎng) 版權(quán)所有
經(jīng)營(yíng)性網(wǎng)站備案信息

京公網(wǎng)安備11010502032929號(hào)

工商備案公示信息

京ICP證050801號(hào)

京ICP備12003651號(hào)

主站蜘蛛池模板: 临潭县| 会东县| 仁寿县| 河南省| 深水埗区| 泰兴市| 科尔| 阜宁县| 三亚市| 平乡县| 卢氏县| 钟山县| 镇宁| 梅河口市| 清镇市| 澄迈县| 美姑县| 岗巴县| 措勤县| 阳新县| 栖霞市| 四子王旗| 色达县| 张掖市| 泸州市| 江永县| 冕宁县| 长兴县| 怀仁县| 临夏县| 赫章县| 永新县| 家居| 沾益县| 河津市| 永善县| 壶关县| 海口市| 林甸县| 上栗县| 阳原县|