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an implantable

trilayer structured fiber device is developed to achieve time-programmed

release of combined drugs for synergistic treatment of breast cancer. The

fiber device is prepared by a modified microfluidic-electrospinning technique.

The glycerol solution containing chemotherapy agent doxorubicin (Dox)

forms the internal periodic cavities of the fiber, and poly(l-lactic acid) and

poly(ε-caprolactone) containing the angiogenesis inhibitor apatinib (Apa)

form the double walls of the fiber. Rapid release of Dox can be obtained by

adjusting the wall thickness of the cavities, meanwhile sustained release of

Apa is achieved through the slow degradation of the fiber matrix. After the

fiber device is implanted subcutaneously near to the implanted solid tumor

of mice, an excellent synergistic therapeutic effect is achieved through timeprogrammed

release of the combined dual drugs. The fiber device provides

a platform to sequentially co-deliver dual or multiple drugs for enhanced