[RSC Adv.] Biocompatible amphiphilic hyperbranched nanocapsules with a functional core: Synergistic encapsulation and asynchronous release properties towards multi-guest molecules
writer：Wei Tian,* Anlin Lv,* Yunchuan Xie, Xiaoying Wei, Bowu Liu and Xiaoyan Lv
keywords：Hyperbranched nanocapsules，Multi-guest molecules，Synergistic encapsulation and asynchronous release
source：期刊
specific source：RSC Adv., 2012, 2, 11976–11987
Issue time：2012年
To achieve an encapsulation–release property towards multi-guest molecules, amphiphilic hyperbranched nanocapsules (AHN) consisting of a functional hyperbranched poly(b-cyclodextrin) [HBP(b-CD)] core and a methoxy polyethylene glycol shell was first constructed by click chemistry. The encapsulation–release capacity and corresponding mechanism of AHN towards multi-guest molecules were investigated by fluorescence and UV-vis spectroscopy. The results indicated that the encapsulation–release properties of AHN were pH dependent and can be applied to multi-guest systems. The multi-guest encapsulation capacity of AHN was derived from the synergistic encapsulation phenomenon of different guest molecules and the molecular recognition property of the HBP(b-CD) core. Compared with single-guest systems, AHN displays a sustained release characteristic accompanied by an ‘‘a(chǎn)synchronous release phenomenon’’ in multi-guest release systems. The release rate can also be effectively controlled because of the molecular recognition property of the HBP(b-CD) core. Both in vitro cell apoptosis and in vivo systematic toxicity assays confirmed that AHN possessed good biocompatibility.
全文鏈接：http://pubs.rsc.org/en/content/articlelanding/2012/ra/c2ra21333h#!divAbstract