Vancomycin-Assisted Green Synthesis of Reduced Graphene Oxide for Antimicrobial Applications
作者：LiQun Xu, YanBiao Liao, NingNing Li, YiJian Li, JieYu Zhang, YunBing Wang, XueFeng Hu, ChangMing Li
關(guān)鍵字：green reduction, reduced graphene oxide, vancomycin, antibacterial, film
論文來源：期刊
具體來源：https://doi.org/10.1016/j.jcis.2018.01.014
發(fā)表時間：2018年
Chemical reduction of graphene oxide (GO) is a simple and inexpensive method for the large-scale production of graphene-based materials. A suitable reducing agent, especially a green reductant, is in high demand for the production of reduced GO (RGO). Vancomycin, a glycopeptide antibiotic used to treat a variety of Gram-positive bacterial infections, was used to chemically reduce GO at a weak alkaline pH. As far as we know, this is the first report of reduction of GO by a glycopeptide antibiotic. The resulting vancomycin-decorated RGO (RGO-Van) was characterized by UV-visible adsorption and Raman spectroscopies, X-ray diffraction pattern and atomic force microscopy (AFM). The antibacterial effect of the RGO-Van suspension was investigated by the bacterial growth curves. The RGO-Van sheet can be fabricated into paper-like film through vacuum filtration. The antibacterial property of the as-obtained RGO-Van film was assessed by the inhibition zone test, and the bacterial adhesion assay. The antibacterial efficacy of the RGO-Van film was also verified by treatment of wound infection caused by Staphylococcus aureus (S. aureus) in a rat infection model.