私密直播全婐app免费大渔直播,国产av成人无码免费视频,男女同房做爰全过程高潮,国产精品自产拍在线观看

相關鏈接
聯(lián)系方式
  • 通信地址:吉林省吉林市龍?zhí)秴^(qū)承德街45號
  • 郵編:132022
  • 電話:0432-25358645
  • 傳真:
  • Email:yhyqdu@163.com
當前位置:> 首頁 > 論文著作 > 正文
Construction of redox/pH dual stimuli-responsive PEGylated polymeric micelles for intracellular doxorubicin delivery in liver cancer
作者:Hong Yu Yang, Moon-Sun Jang, Guang Hui Gao,c Jung Hee Lee, Doo Sung Lee*
關鍵字:stimuli-responsive, micelles, DOX
論文來源:期刊
具體來源:DOI https://doi.org/10.1039/C5PY01808K
發(fā)表時間:2016年

A new type of redox and pH dual-responsive biodegradable polypeptide micelle was developed based on the disulfide-linked methoxy poly(ethylene glycol)-b-poly[2-(dibutylamino)ethylamine-L-glutamate] (mPEG-SS-PNLG) copolymer and applied as an efficient and intelligent carrier to rapidly trigger the intracellular release of doxorubicin (DOX). The mPEG-SS-PNLG was synthesized by a combination of ring-opening polymerization using mPEG-cystamine as a macroinitiator and a side-chain aminolysis reaction. The cumulative release profile of the DOX-loaded mPEG-SS-PNLG (DOX-mPEG-SS-PNLG) micelles indicated a low level of drug release (approximately 25 wt% within 24 h) at pH 7.4, which was significantly accelerated at a lower pH of 5.0 and a higher reducing environment (over 95 wt% in 24 h), demonstrating unambiguous redox/pH dual-responsive controlled drug release capability. An in vitrocytotoxicity test indicated that empty mPEG-SS-PNLG micelles were nontoxic to HepG2 cells up to a tested concentration of 200 μg mL?1. Confocal laser scanning microscopy observations revealed that DOX-loaded mPEG-SS-PNLG micelles efficiently released DOX into human hepatocellular carcinoma HepG2 cells following 24 h of incubation. Importantly, the DOX-loaded mPEG-SS-PNLG micelles significantly increased in vivo therapeutic efficacy toward HepG2 cells in comparison with the free-DOX and control groups. The successful demonstrations indicate that redox and pH dual-responsive mPEG-SS-PNLG micelles are promising candidates for delivering anti-cancer drugs.


主站蜘蛛池模板: 全椒县| 遂川县| 潢川县| 新余市| 闸北区| 怀宁县| 天长市| 凉城县| 鹰潭市| 葫芦岛市| 益阳市| 那曲县| 伊宁县| 宝坻区| 石河子市| 固阳县| 高青县| 乳山市| 连江县| 洪湖市| 鹰潭市| 哈巴河县| 铜陵市| 吴桥县| 玛沁县| 班戈县| 乌苏市| 诸暨市| 兖州市| 滨海县| 北辰区| 嘉祥县| 阜新| 汉寿县| 凤山市| 连平县| 海门市| 新平| 玉环县| 丹棱县| 湖州市|