Enhanced pH stability, cell viability and reduced degradation rate of poly(L-lactide)-based composite in vitro: effect of modified magnesium oxide nanoparticles.
writer：Yang Jinjun, Cao Xiuxiang, Zhao Yun, Wang Liang, Liu Bei, Jia Junping, Liang Hui, Chen Minfang
keywords：Poly(L-lactide); magnesium oxide nanoparticle, modification, in vitro
source：期刊
specific source：Journal of Biomaterials Science, Polymer Edition
Issue time：2017年
The modified MgO nanoparticles (m-MgO-NPs) by a copolymer
containing the malic acid and low molecular weight poly(L-lactide)
(poly(L-lactide-co-malic acid), PLMA) have been successfully
prepared. MgO nanoparticles (MgO-NPs) were coated by the PLMA
and m-MgO-NPs were uniformly dispersed in the PLLA matrix to a
novel biocomposite material (PLLA/m-MgO-NPs) with more excellent
interface bonding and uniformer dispersion, compared to the
PLLA/MgO-NPs. Compared to neat PLLA and PLLA/MgO-NPs film,
the m-MgO-NPs not only shown the obvious neutralization effect
on the acidic solution in the degradation of the PLLA and better
hydrophilicity, but also exhibited the higher cell viability and decrease
the toxicity to the cell in the degradation process of PLLA in vitro.
In addition, m-MgO-NPs also reduced the degradation rate of the
PLLA. The mechanisms for the excellent dispersion of nanoparticles,
enhanced pH stability, reduced degradation rate of the PLLA and the
cell viability in vitro in the case of PLLA/m-MgO-NPs have also been
proposed and discussed in detail.