Preparation of Magnetite and Tumor Dual-targeting Hollow Polymer Microspheres with pH-Sensitivity for Anticancer Drug-carriers
writer：Xiaoying Yang* , Lei Chen, Bin Han, Xinlin Yang*, and Hongquan Duan
keywords：pH-sensitivity; Anti-cancer drug carriers; Polymer microsphere
source：期刊
specific source：Polymer, 51 (12), 2533-2539 (2010). DOI: 10.1016/j.polymer.2010.04.032
Issue time：2010年
The hollow poly(N,N0-methylenebisacrylamide-co-methacrylic acid) (P(MBAAm-co-MAA)) microspheres were prepared by the selective removal of poly(methacrylic acid) (PMAA) core from the corresponding PMAA/P(MBAAm-co-MAA) core-shell microspheres, which were synthesized via a two-stage distillation precipitation polymerization. The magnetic Fe3O4 nanoparticles onto the surface of hollow P(MBAAm-co-MAA) microspheres via partial oxidation of ferrous salt during the chemical deposition in the presence of
potassium nitrate as oxidant with the aid of hexamethylene tetramine and the magnetic hollow microspheres were further functionalized with folic acid (FA) via the chemical linkage with amino groups of 3-aminopropyl triethoxysilane (APS)-modified P(MBAAm-co-MAA)@Fe3O4 microspheres to afford the magnetite and tumor dual-targeting hollow microspheres. The resultant dual-targeting hollow polymer microspheres with pH-sensitivity were characterized by transmission electron microscopy (TEM), dynamic
light scattering (DLS), Fourier transform infrared-spectrometer (FT-IR), UVevis absorption spectroscopy, and vibrating sample magnetometer (VSM). Finally, the drug loading capacities of the magnetite and tumor dual-targeting hollow P(MBAAm-co-MAA) microspheres and their releasing dependence on pH values were investigated with doxorubicin hydrochloride (DXR) as an anticancer drug model.