于明明，教授，碩士生導師。
1998年畢業于吉林大學。2005年5月于中科院理化所獲博士學位。清華大學化學系博士后工作后，2007年到鄭州大學工作。先后被評為校級青年骨干教師、省級青年骨干教師。2017年8月-2018年8月在美國新澤西理工學院進行訪學研究。
主要從事生物熒光分子探針和熒光高分子的研究。任職以來主持國家自然科學基金兩項，參與一項，在Org. Lett.、Chem. Commun.、Inorg. Chem.、Langmuir、Anal. Chem.、J. Mater.
Chem. C等雜志上發表論文四十余篇。2010年9月發表在Chem. Commun.的論文下載次數為當月該雜志的第三。2012年9月發表在New J. Chem.的文章為當月該雜志下載次數Top-Ten的第一。為Biosensors
and Bioelectronics、Sensors and Actuators B、Analytica
Chimica Acta、Dyes and Pigments等雜志的審稿人，2019年開始為“中國化學快報”青年編委。
聯系方式
電子郵件：yumm@zzu.edu.cn
個人網址：https://www.x-mol.com/groups/yu_mingming
實驗室：化學實驗樓121
通訊地址：鄭州大學化學與分子工程學院 450001
招生專業：物理化學（功能材料方向）
研究興趣：
生物熒光探針
研究具有高靈敏性、快速響應、高空間分辨率的熒光小分子、納米復合物和生物高分子探針，探討探針的識別機制，用于生物體內一些重要生理過程生命相關的熒光成像。
熒光功能高分子材料
研究高分子的熒光響應、能量傳遞、生物模擬以及高分子結構與熒光相互作用的規律。這方面研究期望用于熒光離子捕獲、熒光染料以及生物標記與藥物輸運領域。
主持的研究課題：
國家自然科學基金“羧酸酯酶的上轉換復合納米近紅外比率發光探針的制備及其生物成像”（項目批準號：U1704161）
鄭州大學化學與分子工程學院“青年學術骨干”教師基金
國家自然科學基金“具有雙識別協同作用的鋅、銅離子熒光分子探針”（項目批準號：50903075）
中國科學院光化學轉換與功能材料重點實驗室開放課題“人造捕光天線的分子設計與應用”
橫向課題“新型顯色離子吸附劑的研制”
近期代表文章：
1. Zhang, Q.; Bu, D.D.; Yu, M.M.*; Zhang, H.Y.*; Li, Z.X.* Synthesis of a NIR fluorescene dye and its application for rapid detection
of HSO3? in living cells. Dyes Pigments, 2021, accepted.
2. Lin,
X.M.; Liu, W.J.; Xu, S.Y.; Li, Z.X.*; Zhang, H.Y.*; Yu, M.M.* Imaging of intracellular
bisulfate based on sensitive ratiometric fluorescent probes. Spectrochim. Acta A, 2021, accepted.
3. Liu,
W.J; Yang, C.C.; Zhang, H.Y.*; Li, Z.X.*; Yu,
M.M.* Colorimetric and
ratiometric fluorescence detection of HSO3? with a NIR
fluorescent dye. J. Fluoresc. 2021, published online, Early
Access.
4. Yang, C.C.; Song, J.S.; Ding, Y.; Ren, H.H.; Yu,
M.M.*; Zhang, H.Y.*; Li, Z.X.* Solvent-dependent tautomeric
equilibrium between fluorescent colorimetric probes with dual
mitochondrial/liposome targetability. Dyes Pigments, 2021, 191, 109377.
5. Bu,
D.D.; Wang, Y.Y.; Wu, N.; Feng, W.; Wei, D.H.; Li,
Z.X.*; Yu, M.M.* A mitochondrial-targeted
ratiometric probe for detecting intracellular H2S with high photostability. Chin. Chem. Lett., 2021, 32, 1799–1802.
6. Zhang, Q.; Song, H.H.; Yu, M.M.*; Zhang, H.Y.*; Li, Z.X.* Preparation of yellow fluorescent N,O-CDs and its application in detection
of ClO-. J. Fluoresc. 2021, 31, 659–666.
7. Yang, C.C.; Li, Y.Y.; Wu, N.; Zhang, Y.C.; Feng, W.; Yu, M.M.*; Li, Z.X.* Ratiometric upconversion luminescence
nanoprobes for quick sensing of Hg2+ and cells imaging. Sens. Actuators B, 2021, 326, 128841.
8. Hou, Y.; Liu, H.X.;
Li, Z.X.*; Zhang, H.Y.*; Wei, L.H.; Yu, M.M.* One-step
synthesis of mitochondrion-targeted fluorescent carbon dots and fluorescence detection
of silver ions. Anal. Methods, 2020, 12,
2835–2840.
9. Bu, D.D.; Song, H.H.; Li, Z.X.*; Wei, L.H.; Zhang, H.Y.*; Yu, M.M.* Carbon-dot-based ratiometric fluorescent probe
of intracellular zinc ion and persulfate ion with low dark toxicity. Luminescence, 2020, 1–9. DOI:
10.1002/bio.3894.
10. Liu, W.J.; Wang, Y.Y.;
Wu, N.; Feng, W.; Li, Z.X.*; Wei, L.H.; Yu, M.M.* A mitochondrion-targeting fluorescent probe
for hypochlorite anion in living cells. Spectrochim. Acta A, 2020, 240, 118564.
11. Li, Y.Y.; Ban, Y.N.;
Wang, R.H.; Wang, Z.; Li, Z.X.*; Fang, C.J.; Yu, M.M.* FRET-based Ratiometric Fluorescent Detection of Arginine in Mitochondrion
with a Hybrid Nanoprobe. Chin. Chem. Lett., 2020, 31, 443–446.
12. Wang,
Y.Y.; Liu, H.X.; Song, H.H.; Yu, M.M.*; Wei,
L.H.; Li, Z.X.* Synthesis of dual-emission fluorescent
carbon quantum dots and their ratiometric fluorescence detection for arginine
in 100% water solution. New
J. Chem., 2019, 43, 13234?13239.
13. Li,
Z.X.; Liu, H.X.; Li,
H.X.; Tsou, Y.H.; Gao, Y.L.; Xu, X.Y.*; Du, W.W.; Wei, L.H.; Yu, M.M.*
Lysosome-targeting NIR Ratiometric Luminecent Upcoversion Nanoprobe toward
Arginine. Sens. Actuators B, 2019, 280,
94–101.
14. Song,
H.H.; Du, W.W.; Liu, C.X.; Li, Z.X.*; Zhang, H.Y.*; Wei, L.H.; Yu, M.M.* Self-Assembled
Micellar Nanosensor toward pH with high photo-stability and its application in
living cells. Sens. Actuators B, 2018, 273, 927–934.
15. Ban,
Y.; Wang, R.H.; Li, Y.; An, Z.; Yu, M.M.*; Fang, C.J.*; Wei, L.; Li, Z.X. Mitochondria-targeted
ratiometric fluorescent detection of hydrazine with fast response time. New
J. Chem., 2018, 42, 2030?2035.
16. Shi, B. J.; He,Y. Y.; Zhang, P. P.; Wang,
Y. L.; Yu, M. M.*; Zhang, H. Y.*; Wei, L. H.; Li, Z. X.* Turn on fluorescent detection of hydrazine with a 1,8-naphthalimde
derivative. Dyes Pigments, 2017,
147, 152–159.
17. He,Y. Y.; Li, Z. X.*; Jia, Q. Y.; Shi, B. J.; Zhang, H. Y.*; Wei, L. H.; Yu, M. M.* Ratiometric
fluorescent detection of acidic pH in lysosome with carbon nanodots. Chin. Chem.
Lett., 2017, 28(10), 1969-1974.
18. Li, H. X;
Dong, H.; Yu, M. M.; Liu, C. X.; Li, Z. X.; Wei, L. H.; Sun, L.
D.; Zhang, H. Y. NIR ratiometric luminescence detection of pH fluctuation in
living cells with hemicyanine derivative-assembled upconversion nanophosphors. Anal. Chem., 2017, 89,
8863?8869.
19. Shi,
B. J.; Qi, S. J.; Yu, M. M.; Liu, C. X.; Li, Z. X.; Wei, L. H.; Ni, Z. H. Colorimetric and fluorescent detection of hydrazine with high sensitivity
and excellent selectivity. Spectrochim. Acta A, 2018, 188, 208–212.
20. He,Y. Y.; Li, Z. X.; Shi, B. J.; An, Z.; Yu, M. M.; Wei, L. H.; Ni, Z. H. A new near-infrared ratiometric fluorescent
probe for hydrazine. RSC Adv., 2017, 7, 25634–25639.
21. Yu, M. M.*; Du, W. W.; Li, H. X.; Zhang, H. Y.*; Li, Z. X.* Near-infrared ratiometric
fluorescent detection of arginine in lysosome with a new hemicyanine derivative. Biosens. Bioelectron., 2017, 92, 385–389.
22. An, Z.; Li, Z. X.*; He, Y.; Shi, B.; Wei, L.; Yu, M. M.* Ratiometric
luminescent detection of hydrazine with a carbon dots-hemicyanine nanohybrid
system. RSC Adv., 2017, 7, 10875–10880.
23. Li, Z. X.;* Zhang, W. Y.; Liu, C. X.; Yu, M. M.*; Zhang,
H. Y.*; Guo, L.; Wei, L. H. A colorimetric and ratiometric fluorescent
probe for hydrazine and its application in living cells with low dark toxicity. Sens. Actuators B, 2017, 241, 665–671.
24. Shi,
B. J.; Gao, Y. L.; Liu, C. X.; Feng, W. Li, Z. X.; Wei, L. H.; Yu, M. M.* A ratiometric fluorescent sensor for pH
fluctuation and its application in living cells with low dark toxicity. Dyes
Pigments, 2017, 136,
522–528.
25. Li,
Z. X.; Li,
H. X.; Shi, C. X.; Yu, M. M.; Wei, L. H.; Ni
Z. H. Nanomolar colorimetric quantitative detection of Fe3+ and PPi with
high selectivity. Spectrochim. Acta A, 2016, 159, 249–253.
26. Yu, M. M.*, Du, W. W.; Zhou, W.; Li, H. X.; Liu,
C. X.; Wei, L. H.; Li, Z. X.*; Zhang, H. Y. A 1,8-naphthalimide-based
chemosensor with an off-on fluorescence and lifetime imaging response for
intracellular Cr3+ and further for S2?. Dyes Pigments, 2016, 126, 279–285.
27. Li,
Z. X.*; Li, H. X.; Shi, C. X.; Zhang, W. Y.; Zhou, W.; Wei, L. H.; Yu, M. M.*
Naked-eye-based highly selective sensing of Fe3+ and further for PPi
with nano copolymer Film. Sens. Actuators B, 2016, 226, 127–134.
28. Yu, M. M.*; Xu, J.;
Peng, C.; Li, Z. X.; Liu, C. X.; Wei, L. H. A novel colorimetric and fluorescent probe for detecting fluoride
anions: from water and toothpaste samples. Tetrahedron, 2016, 72, 273–278.
29. Xu, L. J.; Liang, X. Y.; Zhang, L.; Wu, J. B.; Li, Z. X.; Yu, M. M.*; Wei, L. H.* The
vesicle formation of β-CD and AD
self-assembly of dumbbell-shaped amphiphilic triblock copolymer. Colloid Polym. Sci., 2016, 294, 145–155.
30. Zhang, W. Y.; Liu, X. J.; Zhang, H. Y.; Feng, C. C.; Liu, C. X.; Yu, M. M.*; Wei, L. H.; Li, Z. X.* A fluorescent probe for benzenethiols and
its application on test paper, in water samples and living cells. J. Mater.
Chem. C, 2015, 3,
8248–8254.
31. Liu, C. X.;
Shi, C. X.; Li, H. X.; Du, W. W.; Li, Z. X.*; Wei, L. H.; Yu, M. M.*
Nanomolar fluorescent quantitative detection of formaldehyde with a
8-hydroxyquinoline derivative in aqueous solution and electrospun nanofibers. Sens.
Actuators B, 2015, 219, 185–191.
32. Li, Z. X.*; Zhang, W. Y.; Liu, X. J.; Liu, C. X.; Yu, M. M.*; Wei, L. H.* Naked-eye-based selective detection of
pyrophosphate with Zn2+ complex in aqueous solution and electrospun
nanofibers. RSC Adv., 2015, 5, 25229–25235.
33. Liu, C. X.; Xu, J.; Yang, F.; Zhou, W.; Li, Z. X.*; Wei, L. H.; Yu, M. M.* Nanomolar Cu2+ and F– naked-eye detection with a 1,8-naphthalimide-based colorimetric probe. Sens. Actuators B, 2015, 212, 364–370.
34. Du, W. W.; Xu,
J.; Li, H. X.; Feng, C. C.; Yu, M. M.*; Li Z. X.;* Wei L. H. Naked-eye and fluorescent detection of basic pH and F? with a 1,8-naphthalimide-based multifunctional
probe. RSC Adv., 2015, 5,
15077–15083.
35. Zhou, W.; Dong, H.; Yan, H.; Shi, C. X.; Yu, M. M.*; Wei, L.
H.; Li, Z. X.* HCHO-reactive
molecule with dual-emission-enhancement property for quantitatively detecting HCHO
in near 100% water solution. Sens.
Actuators B, 2015, 209, 664–669.
36. Liu, X. J.; Zhang, W.Y.; Li, C. X.; Zhou, W.;
Li, Z. X.*; Yu, M. M.*; Wei, L. H. Nanomolar detection of Hcy, GSH
and Cys in aqueous solution, test paper and living cells. RSC Adv., 2015, 5, 4941–4946.
37. Li, Z. X.*;
Liu, X. J.; Zhao, W. Y.; Wang, S.; Zhou, W.; Wei, L. H.; Yu, M. M.* Naked-eye
detection of C1–C4 alcohols based on ground-state intramolecular proton transfer. Anal. Chem., 2014, 86,
2521?2525.
38. Su, Z.; Huang,
S. S.; He, M.; Dong, C. F.; Wu, L. Z.; Li, C. H.; Liu, J. X.; Yu, M. M.*; Wei, L. H.* Synthesis and antibacterial performance of silver bromide
and silver nanoparticles J. Nanoeng. and
Nanomanuf. 2014, 4(4), 330?335.
39. Liu, X. J.;
Chen, M. X.; Liu, Z. P.; Yu, M. M.*; Wei,
L. H.; Li, Z. X.* Synthesis
of 1,8-naphthyridine and BF2-based isomers and their application in
fluorogenic sensing Cd2+ Tetrahedron 2014, 70,
658?663.
40. Yu, M. M.*; Yuan,
R. L.; Shi, C. X.; Zhou, W.; Wei, L. H.; Li, Z. X.* 1,8-Naphthyridine
and 8-hydroxyquinoline modified Rhodamine B derivatives: “Turn-on” fluorescent
and colorimetric sensors for Al3+ and Cu2+ Dyes Pigments 2013, 99, 887?894.
41. Li, X. Y.; Yu, M. M.; Liu, X. J.; Yang,
F. L.; Wei,
L. H.; Li, Z. X.* A dual-mode
ratiometric and on?off fluorescent Al3+/Cu2+-chemosensor
and the detection of F?/Al3+ with ‘in situ’ prepared Al3+/Cu2+ complex in aqueous solution. New J. Chem. 2013, 37, 2257?2260.
42. Li, H. Q.; Li,
Z. X.*; Wu, L. Z.; Zhang, Y. N.; Yu, M. M.*; Wei, L. H.* Constructing
metal nanoparticle multilayers with polyphenylene dendrimer/gold nanoparticles via “click” chemistry. Langmuir 2013, 29, 3943?3949.
43. Li, Z. X.;
Zhou, W.; Zhang, L. F.; Yuan, R. L.; Liu, X. J.; Wei, L. H.; Yu, M. M.* Highly selective ratiometric fluorescent detection of Fe3+ with a
polyphenyl Derivative, J. Lumin. 2013, 136, 141?144.
44. Li, Z. X.; Zhao, W. Y.; Li, X. Y.; Zhu, Y. Y.; Liu, C. M.; Wang, L. N.; Yu, M. M.*; Wei, L. H.; Tang, M. S.; Zhang, H. Y.* 1,8-Naphthyridine-derived Ni2+/Cu2+-selective
fluorescent chemosensor with different charge transfer processses. Inorg. Chem. 2012, 51, 12444?12449.
45. Wang, L. N., Yu,
M. M.*, Liu, Z. T., Zhao, W. Y., Li, Z. X.,* Ni, Z. H., Li, C. C., Wei, L. H.* A visible
light excitable “on-off” and “green-red” fluorescent chemodosimeter for Ni2+/Pb2+ New J. Chem. 2012, 36, 2176–2179.
46. Li, Z. X.; Zhang, L. F.; Li, X. Y.; Guo, Y. K.; Ni, Z. H.; Chen, J. H.; Wei, L.
H.; Yu, M. M.* A fluorescent color/intensity changed chemosensor for Fe3+ by
photo-induced electron transfer (PET) inhibition of fluoranthene derivative. Dyes
Pigm. 2012, 94, 60–65.
47. Huiqiang Li, Zhanxian
Li, Linzhi Wu, Fang Liu, Jie Zhou, Miao Luan, Mingming Yu*, Liuhe Wei* Water-Soluble
Starlike Poly(acrylic acid) Graft Polymer: Preparation and Application as
Templates for Silver Nanoclusters Polym. Bull., 2012, 68, 2229–2242.
48. Zhanxian
Li, Wanying Zhao, Yuna Zhang, Lifeng Zhang, Mingming Yu*, Jinxia Liu* and Hongyan Zhang* An “off-on”
fluorescent chemosensor of selectivity to Cr3+ and its application
to MCF-7 cells Tetrahedron, 2011, 67, 7096–7100.
49. Zhan-Xian Li, Li-Feng Zhang, Wan-Ying Zhao, Xiao-Ya Li, Yong-Kai
Guo, Ming-Ming Yu*, Jin-Xia
Liu* Fluoranthene-based pyridine as fluorescent chemosensor for Fe3+ Inorg. Chem.
Commun., 2011, 14, 1656–1658.
50. Zhanxian Li, Lifeng Zhang, Lina Wang,
Yongkai Guo, Lianheng Cai, Mingming
Yu,*
Liuhe Wei* Highly Sensitive and
Selective Fluorescent Sensor for Zn2+/Cu2+ and New Approach for Sensing Cu2+ by Central Metal Displacement Chem. Commun., 2011, 47, 5798–5800.
51. Zhanxian Li, Mingming Yu,* Lifeng
Zhang, Ming Yu, Jinxia Liu, Liuhe Wei,* and Hongyan Zhang* A “switching
on” fluorescent chemodosimeter of selectivity to Zn2+ and its application to MCF-7 cells Chem. Commun., 2010, 46, 7169–7171.
52. Ming Ming Yu, Xia
Li, Miao Luan, Jun Na Gao, Qiu Zhi Shi, Ming Sheng Tang, Liu He Wei
An improved synthesis of bis(cyclopentadienone) Chin. Chem. Lett., 2010, 21, 1157–1161.
53. Ming-Ming Yu, Zhan-Xian Li, Liu-He Wei, Dong-Hui Wei, Ming-Sheng Tang A
1,8-Naphthyridine-based Fluorescent Chemodosimeter for the Rapid Detection of
Zn2+ and Cu2+ Org.
Lett. 2008, 22(10), 5115–5118.
54. Ming-Ming Yu, Hui-Zhong Kou, Zhong-Hai Ni, Chong-Chao Zhao, Ai-Li Cui Synthesis and
Study of Ferromagnetic μ1,1-Azido-Bridged Manganese(II) Dinuclear
Complexes with S=5 and S = 5 × 2 2 Ground State Eur. J. Inorg. Chem. 2007,
5670– 5676.
授權專利：
· 于明明、李占先、杜瑋瑋、李海霞、魏柳荷，一種溶酶體定位熒光探針在近紅外比率檢測肼中的應用。2016.10.20，中國，專利號：ZL201610923191.8
· 于明明、施冰杰、劉春霞、李占先、魏柳荷，一種線粒體靶向的pH敏感的比率型熒光探針及其制備方法和應用。2016.07.06，中國，專利號：ZL201610221971.8
· 于明明、張文英、李占先、石彩霞、周婉、魏柳荷，一種高分子比色納米薄膜材料及其制備方法以及用于Fe3+和焦磷酸根檢測方面的應用。2015.05.26，中國，專利號：ZL201510292665.9
· 于明明、李海霞、嚴晗、周婉、李占先、魏柳荷，一種甲醛快速檢測試劑及其制備方法與應用。2016.11.02，中國，專利號：ZL201410500026.2
· 于明明、張文英、劉興江、周婉、李占先、魏柳荷，一種檢測焦磷酸根的納米纖維膜試條、制備方法及其應用。2015.11，中國，專利號：ZL201410402826.0
· 于明明、李占先、魏柳荷、劉興江，一種氟硼熒光衍生物、其制備方法及應用。2015.11，中國，專利號：ZL201310171197.0
· 于明明、喬鈺茜、李占先、魏柳荷、郭永開，2,4-二苯基-5,6-二吡啶基-苯酚及其制備。2015.6，中國，專利號：ZL201310518992.2
· 李占先、班亞楠、于明明、李海霞、劉春霞、魏柳荷，一種用于制備近紅外比率發光上轉換納米材料的化合物、制備方法及應用。2016.12.01，中國，專利號：ZL201611120950.3
· 李占先、于明明、魏柳荷、劉興江、趙萬瑩、周婉，一種低級醇檢測探針、制備方法及應用。2015.4，中國，專利號：ZL201310198342.4
· 于明明、李占先、魏柳荷、張利鋒、趙萬瑩、王麗娜，苯衍生物金屬離子熒光探針及其應用。2014.4，中國，專利號：ZL201110169893.9
· 李占先、于明明、張利鋒、虞明、魏柳荷、劉金霞，一種檢測細胞內鋅離子的分子熒光開關及其應用。2013.4，中國，專利號：ZL201010181802.9。
· 李占先、于明明、魏柳荷、張利鋒、趙萬瑩、王麗娜，萘聯苯衍生物金屬離子熒光探針的制備及其識別檢測生物樣品或環境中Fe3+和/或Cu2+的應用。2013.4，中國，專利號：ZL201110169892.4。
教育教學相關
2014年和2016年年終考核被評為優秀；
2011年發表教改論文一篇（物理化學實驗教學的體會與思考）；
2016年發表教改論文一篇（高校全員育人的三級管理體系新探）；
2013、2014、2015和2016年化學學院高分子化學理論課網上教評均為優秀；
2013、2014和2015年藥學院物理化學理論課網上教評優秀；
2013、2014和2016年物理化學實驗課網上教評優秀；
2015年綜合化學實驗課網上教評優秀；
2013年和2014年兩次被評為平安校園工作先進個人，2015年被評為工會工作積極分子；
先后擔任2014級化學8班班主任和2016級化學1班班主任，作為2014級化學8班班主任2015年和2016年兩次被評為鄭州大學優秀班主任；
指導的本科生畢業論文多次獲得院優秀畢業論文（齊素杰、楊帆等）。
培養研究生情況
在讀研究生
· 卜丹丹、楊晨辰、劉文靜（18級）
· 劉文潔、張強、林雪梅（19級）
· 趙曉軍、魏萬恒、張申、王蕙麗（20級）
已畢業研究生
· 張利鋒（08級）
· 王麗娜（09級）、趙萬瑩（09級）
· 郭永開（10級）、李小鴨（10級）
· 袁瑞麗（11級）、劉興江（11級）
· 周婉、許潔、石彩霞（12級）
· 劉春霞、張文英（13級）
· 杜瑋瑋、何楊楊、安楨（14級）李海霞（11級本碩）
· 施冰杰（15級）
· 班亞楠、宋歡歡、劉含笑（16級）
· 王鈺瑩、李月月、侯玥（17級）
研究生及本科生所獲部分獎勵
2013年
袁瑞麗獲得康龍化成獎學金
袁瑞麗、周婉獲得國家獎學金
2014年
劉興江獲得校級及省級優秀畢業生
劉興江獲得省級優秀畢業論文
張文英獲得鄭州大學優秀科研獎
2015年
周婉獲得鄭州大學優秀畢業生
齊素杰獲得鄭州大學優秀畢業論文
張文英、劉春霞獲得國家獎學金
2016年
楊帆獲得院優秀畢業論文
杜瑋瑋、施冰杰獲得鄭州大學優秀科研獎
李海霞、杜瑋瑋獲得國家獎學金
張文英獲得省級優秀畢業論文
2017年
李海霞、杜瑋瑋獲得鄭州大學優秀畢業生
杜瑋瑋獲得省級優秀畢業論文
施冰杰或省級大學生實驗創新項目優秀獎