[Synthesis] Efficient and Divergent Synthesis of Functionalized Cyclopropanes via Iodoform Reaction
作者：Dingyuan Zhang, Rui Zhang, Dexuan Xiang, Ning Zhang,* Yongjiu Liang, Dewen Dong*
關(guān)鍵字：cyclopropanes, iodoform reaction, iodine, amide
論文來源：期刊
具體來源：Synthesis
發(fā)表時(shí)間：2012年
Efficient and divergent one-pot synthesis of cyclopropyl amides and esters from readily available 1-acetylcyclopropanes via iodoform reaction based on reaction conditions selection is reported. A series of substituted cyclopropyl amides were synthesized from 1-acetyl-cyclopropanes in the presence of iodine and ammonia in water in good yields, whereas substituted cyclopropyl esters were obtained from the reaction of 1-acetylcyclopropanes with iodine and alcohols in the presence of DBU.