私密直播全婐app免费大渔直播,国产av成人无码免费视频,男女同房做爰全过程高潮,国产精品自产拍在线观看

相關(guān)鏈接
聯(lián)系方式
  • 通信地址:天津市南開區(qū)衛(wèi)津路94號南開大學化學樓南樓302室
  • 郵編:300071
  • 電話:022-23507193
  • 傳真:
  • Email:zhanghuiqi@nankai.edu.cn
當前位置:> 首頁 > 論文著作 > 正文
Efficient one-pot synthesis of hydrophilic and fluorescent molecularly imprinted polymer nanoparticles for direct drug quantification in real biological samples
作者:Hui Niu, Yaqiong Yang, Huiqi Zhang*
關(guān)鍵字:Molecularly imprinted polymers, chemosensor, nanoparticles, fluorescence quenching, biological samples
論文來源:期刊
具體來源:Biosensors and Bioelectronics 2015, 74, 440-446.
發(fā)表時間:2015年

Efficient one-pot synthesis of hydrophilic and fluorescent molecularly imprinted polymer (MIP) nanoparticles and their application as optical chemosensor for direct drug quantification in real, undiluted biological samples are described. The general principle was demonstrated by preparing tetracycline (Tc, a broad-spectrum antibiotic)-imprinted fluorescent polymer nanoparticles bearing hydrophilic polymer brushes via poly(2-hydroxyethyl methacrylate) (PHEMA) macromolecular chain transfer agent-mediated reversible addition-fragmentation chain transfer (RAFT) precipitation polymerization in the presence of a fluorescent monomer. The introduction of hydrophilic PHEMA brushes and fluorescence labeling onto/into the MIP nanoparticles proved to not only significantly improve their surface hydrophilicity and lead to their obvious specific binding and high selectivity toward Tc in the undiluted bovine serum, but also impart them with strong fluorescent properties. In particular, significant fluorescence quenching was observed upon their binding with Tc in such complex biological milieu, which makes these Tc-MIP nanoparticles useful optical chemosensor with a detection limit of 0.26 μM. Furthermore, such advanced functional MIP nanoparticles-based chemosensor was also successfully utilized for the direct, sensitive, and accurate determination of Tc in another biological medium (i.e., the undiluted pig serum) with average recoveries ranging from 98% to 102%, even in the presence of several interfering drugs. 

主站蜘蛛池模板: 南通市| 天等县| 阳西县| 鄂尔多斯市| 石棉县| 怀仁县| 改则县| 华坪县| 原阳县| 晋江市| 东源县| 菏泽市| 汾西县| 兴隆县| 湘潭县| 九江县| 阳春市| 洪湖市| 万源市| 弥勒县| 淮北市| 金门县| 乳源| 南康市| 南陵县| 连南| 舟曲县| 康平县| 桃园市| 鹤庆县| 湛江市| 玉山县| 明溪县| 西华县| 建昌县| 通州市| 康马县| 从江县| 卢湾区| 黄浦区| 平南县|