Preparation of poly (L-lactic acid) modified polypropylene mesh and its anti-adhesion in experimental abdominal wall defect repair
作者：Zhigang Zhang, Tianzhu Zhang*, Junsheng Li , Zhenling Ji* , Hemei Zhou, Xuefeng Zhou, and Ning Gu*
關鍵字：polypropylene, poly(L-lactic acid), hernia repair, mesh, antiadhesion
論文來源：期刊
發(fā)表時間：2013年
A new type of polypropylene (PP) hernia mesh,
modified with poly(L-lactic acid) (PLLA), was developed and
used to repair rat abdominal wall defect. The PP mesh was
first treated with oxygen plasma and then grafted with PLLA
in phosphorus pentachloride (PCl5) solution in dichloride
methane. The water contact angle changed during the procedure,
and the coverage percentage of PLLA on the PP was
about 80%. ATR-FTIR spectroscopy measurements showed
the existence of carbonyl group absorption peak (1756.9
cm21), and atomic force microscope and scanning electron
microscope morphological observation indicated that the
surface of the PP mesh was covered with PLLA graft. X-ray
photoelectron spectroscopy spectra was used to probe
chemical group changes and confirmed that the PLLA was
grafted onto the PP. A total of 36 Sprague–Dawley rats were
randomly divided into six groups, and they received either
modified meshes (experimental groups) or PP meshes
(control groups) to repair abdominal wall defects. All animals
survived until the end of the experiment. Rats in each
group were dissected after the operation (after 1 week, 2
weeks, and 1 month, respectively), and the adhesion effects
were evaluated. Sections of the mesh parietal peritoneum
overlap were examined histologically and graded for inflammation
reaction. Compared with the control groups, the experimental
groups showed a better ability to resist
peritoneal cavity adhesions (P < 0.05), and there was no
increase in inflammation formation (P > 0.05). This new
type of PLLA-modified PP mesh displayed an additional
property of antiadhesion in animal abdominal wall defect
repair. VC 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B:
Appl Biomater, 102B: 12–21, 2014.