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UNDERSTANDING THE ROLE OF THE C3-HYDROXYL GROUP IN GLYCYRRHETINIC ACID ON LIVER TARGETING

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關(guān)鍵詞：

glycyrrhetinic acid chitosan poly (ethylene glycol) liver
targeting

資料大小：

3383K

所屬學(xué)科：

分子表征

來(lái)源：

SIPCD2010 新型高分子材料與控制釋放國(guó)際會(huì)議論文集（9.14~17，蘇州）

簡(jiǎn)介：

Glycyrrhetinicacid(GA)-modifiedchitosan/poly(ethyleneglycol)nanoparticleswereprepared,inwhichGAasalivertargetingligandwasintroducedatdifferentsites:theC3-hydroxylgroup(CTS/PEG-GA(h)NPs)ortheC30-carboxylgroup(CTS/PEG-GA(c)NPs).Theircharacteristics,especiallytheliVertargetingability,werecompared.ResultsshowedthatthereisnosignificantdifferencebetweentheCTS/PEG-GA(c)NPsandtheCTS/PEG-GA(h)NPsintheirabilitytotargettheliver,indicatingthattheC3-hydroxy1groupinGAhaslittleinfluenceonthetargetingability.

作者：

Qin Tian, xiuhua wang, wei Wang, Chuangnian Zhang, Zhi Yuna, and Xuesi Chen

上傳時(shí)間：

2011-01-27 14:35:04

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