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Temperature-sensitivity and Cell Biocompatibility of Nanocomposite Hydrogels Incorporated with Biodegradable PHBV  
Temperature-sensitivity and Cell Biocompatibility of Nanocomposite Hydrogels Incorporated with Biodegradable PHBV
資料類型: PDF文件
關鍵詞: hydrogels  poly(N-isopropylacrylamide)  
資料大?。?/td> 1599k
所屬學科: 功能高分子
來源: 來源網絡
簡介:
The structure, morphology, thermal behaviors and cytotoxicity of novel hydrogels, composed of poly(N-isopropylacrylamide)(PNIPAM) and biodegradable polyester poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) under nanoclay hectorite “Laponite XLG” severed as physical cross-linker, were characterized by X-ray diffraction, scanning electron microscopy, gravimetric method, differential scanning calorimetry, and cell culture experiments. It was found that, due to the introduction of hydrophobic PHBV, the homogeneity of interior pore in the pure PNIPAM nanocomposite hydrogel was disrupted, the transparency and swelling degree gradually decreased. Although the weight ratio between PHBV and NIPAM increased from 5wt% to 40wt%, the volume phase transition temperature(VPTT) of hydrogels is not altered versus the pure PNIPAM nanocomposite hydrogel. No matter what PHBV content, the PHBV/PNIPAM/Hectorite hydrogels also exhibit good stimuli-responsibility. In addition, human hepatoma cells(HepG2) adhesion and spreading on the surface of PHBV-based hydrogels was greatly improved than that of pure PNIPAM nanocomposite hydrogel at 37 oC due to the introduction of PHBV.
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上傳時間: 2013-02-18 11:25:44
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